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  • Title: Amino acid composition of human liver mitochondrial membranes in normal and pathological conditions.
    Author: Benga G, Hodârnău A, Tilinca R, Borza V, Ferdinand W.
    Journal: Biosci Rep; 1991 Apr; 11(2):95-100. PubMed ID: 1868176.
    Abstract:
    The amino acid composition of proteins from liver mitochondrial membranes has been studied in patients with normal liver, with biliary diseases and fatty liver, with obstructive jaundice or liver cirrhosis. A characteristic pattern of the amino acid composition in patients with normal liver has been found. In the mitochondrial membranes of patients with fatty liver tryptophan and lysine were decreased while [aspartic acid plus asparagine] and [glutamic acid plus glutamine] were increased compared to their counterpart in the normal liver. In patients with obstructive jaundice of short duration (less than two months) only a slight decrease in methionine content was found, while in the case of liver cirrhosis amino acid composition was markedly changed.
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