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  • Title: Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors.
    Author: Bauer D, Whittington DA, Coxon A, Bready J, Harriman SP, Patel VF, Polverino A, Harmange JC.
    Journal: Bioorg Med Chem Lett; 2008 Sep 01; 18(17):4844-8. PubMed ID: 18682324.
    Abstract:
    A novel class of potent and selective inhibitors of KDR incorporating an indazole moiety 1 is reported. The discovery, synthesis, and structure-activity relationships of this series of inhibitors have been investigated. The most promising compounds were also profiled to determine their pharmacokinetic properties and evaluated in a VEGF-induced vascular permeability assay.
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