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  • Title: Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin.
    Author: de Franciscis V, Rosati R, Colucci-D'Amato GL, Eva A, Vecchio G.
    Journal: Cancer Res; 1991 Aug 15; 51(16):4234-7. PubMed ID: 1868443.
    Abstract:
    We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.
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