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  • Title: Mechanisms to explain wasting of muscle and fat in cancer cachexia.
    Author: Argilés JM, López-Soriano FJ, Busquets S.
    Journal: Curr Opin Support Palliat Care; 2007 Dec; 1(4):293-8. PubMed ID: 18685378.
    Abstract:
    PURPOSE OF REVIEW: To describe the most relevant recent findings concerning the molecular mechanisms involved in both fat and muscle tissues in cachectic cancer patients. RECENT FINDINGS: Relevant progress has been made in the mechanism of signalling protein metabolism in skeletal muscle. PI3K has a dual role inhibiting protein degradation by inhibition of Atrogin-1 and MuRF1 gene expression and facilitating AKT phosphorylation, leading to increased protein synthesis. Interestingly, Caspase-3 activity is intimately associated with myofibrillar protein degradation in muscle tissue. With respect to fat metabolism, increased lipolysis in human cancer cachexia seems to be directly connected to increased hormone-sensitive lipase activity. SUMMARY: The results and findings described in this review represent important progress in wasting disease mechanisms and may provide hints for future therapeutic approaches in cancer cachexia.
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