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  • Title: Antagonist peptides of the gliadin T-cell stimulatory sequences: a therapeutic strategy for celiac disease.
    Author: Silano M, Vincentini O, Iapello A, Mancini E, De Vincenzi M.
    Journal: J Clin Gastroenterol; 2008 Sep; 42 Suppl 3 Pt 2():S191-2. PubMed ID: 18685513.
    Abstract:
    Celiac disease (CD) is a T helper 1-driven autoimmune permanent enteropathy, triggered in susceptible individuals by the ingestion of gluten, the alcohol-soluble protein fraction of some cereals, such as wheat, rye, and barley. The only available treatment for CD is the life-long withdrawal of gluten-containing foods from the diet. Complying with gluten-free diet is difficult and affects the quality of life. Therefore, alternative therapies are being investigated. In this paper, we review a new therapeutic strategy for CD, relying upon peptides that are analogs of gliadin T-cell epitopes that show the ability to down-modulate the immune response pathogenic of CD. These peptides have been obtained artificially by amino acids substitution of gliadin T-cell stimulatory sequences and an immunomodulatory sequence has been identified in the alcohol-soluble protein fraction of cultivars of durum wheat.
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