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  • Title: Regulatory elements near the Drosophila hsp 22 gene required for ecdysterone and heat shock induction.
    Author: Rudolph K, Morganelli C, Berger EM.
    Journal: Dev Genet; 1991; 12(3):212-8. PubMed ID: 1868625.
    Abstract:
    A transient expression assay was used to localize cis-acting DNA regulatory elements near the Drosophila heat shock protein (hsp) 22 gene, that are involved in heat shock expression and in ecdysterone-induced expression. The results identify a region between positions -320 and -232 that is essential for ecdysterone control, but not for heat-induced expression, and a sequence between -199 and -156, which, when deleted, leads to the loss of heat shock induction. To investigate the function of these DNA sequences, transfection-competition experiments were carried out. The evidence suggests that the DNA regulatory sequences identified by transient expression studies contain binding sites for transacting transcription factors.
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