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  • Title: [Incidence of seroresistance of syphilis and its relevant factors].
    Author: Wang LN, Zuo YG, Liu YX, Liu XR, Zheng HY.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2008 Jun; 30(3):338-41. PubMed ID: 18686618.
    Abstract:
    OBJECTIVE: To investigate the incidence of seroresistance of syphilis and analyze its relevant factors. METHODS: The clinical data of 131 patients with syphilis were retrospectively analyzed. The incidence of seroresistance was investigated and the correlation between seroresistance and factors including age, gender, original titer, disease course, and medications were analyzed. RESULTS: The incidence of seroresistance was not significantly different among patients with different ages and genders, but was significantly different among patients with different disease courses, antibody titers, and medications. Patients with a baseline serum rapid plasma reagin (RPR) titer of greater than 1: 8, a latent course, or a macrolide therapy history had higher incidences of seroresistance (i. e., 61%, 45.6%, and 72.7% respectively) than those who had a lower RPR titer, a primary course, or a benzathine penicillin therapy history. CONCLUSION: Syphilis patients with a high baseline RPR titer, a latent course, and a macrolides therapy are prone to be seroresistant.
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