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  • Title: Naftifine gel in the treatment of tinea pedis: two double-blind, multicenter studies. Naftifine Gel Study Group.
    Journal: Cutis; 1991 Jul; 48(1):85-8. PubMed ID: 1868748.
    Abstract:
    Three hundred and sixteen patients with a diagnosis of tinea pedis were evaluated in two multicenter, double-blind randomized studies. One hundred and fifty-nine patients applied naftifine gel 1 percent and 157 applied gel vehicle to affected areas twice daily for four weeks. At the end of treatment, the naftifine-treated groups had higher mycologic cure rates (66 percent and 63 percent) than the respective vehicle-treated groups (34 percent and 27 percent, p is less than 0.01 and p is less than 0.001). The rate of global improvement in patients' conditions and the reduction in the incidence and severity of most signs and symptoms was greater for naftifine-treated patients in both studies. The results of these studies indicate that twice-daily use of naftifine gel 1 percent is safe and significantly more effective than vehicle in the treatment of tinea pedis.
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