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  • Title: Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression.
    Author: Suzuki H, Tamai N, Habu Y, Chang MO, Takaku H.
    Journal: FEBS Lett; 2008 Sep 03; 582(20):3085-9. PubMed ID: 18692048.
    Abstract:
    Short-hairpin RNAs (shRNAs) inhibit gene expression by RNA interference. Here, we report on the inhibition, by baculovirus-based vector-derived shRNAs, of core-protein expression in full-length hepatitis C virus (HCV) replicon cells. shRNAs were designed to target the highly conserved core region of the HCV genome. In particular, the core-shRNA452 containing nucleotides 452-472, as the target in the HCV core gene, dramatically inhibited the expression of the HCV core protein in replicon cells. Furthermore, HCV core-protein expression was inhibited more strongly by the vesicular stomatitis virus glycoprotein (VSV-G)-pseudotyped baculovirus vector than by the wild-type baculovirus vector.
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