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  • Title: Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
    Author: Saul N, Pietsch K, Menzel R, Steinberg CE.
    Journal: Mech Ageing Dev; 2008 Oct; 129(10):611-3. PubMed ID: 18692520.
    Abstract:
    The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.
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