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  • Title: [Transport of heterologous DNA in normal and tumor cells and its modification by radiation].
    Author: Shutko AN, Lazovskaia AV, Shatinina NN.
    Journal: Vopr Onkol; 1976; 22(7):51-5. PubMed ID: 186951.
    Abstract:
    The authors have studied in a comparative way the kinetics of incorporation of labelled heterologous DNA in tumor and nontumor cells of an identical histological type, obtained from non-irradiated and irradiated with 800 rad rats. It has been shown that the process of incorporation of heterologous high-polymer DNA in cells is somewhat undulatory, and its temporal characteristics and level -- tissue-specific. Difference between tumor cells and their normal prototype show a quantitative character, conditioned by a large surface area. 30 minutes following the irradiation qualitative changes opposite for both kinds of cells were observed in the kinetics of incorporation: an acceleration for lymphoyctes and retardation for Pliss lymphosarcoma and Zajdela hepatoma cells.
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