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  • Title: Glycine transporters (glycine transporter 1 and glycine transporter 2) are expressed in retina.
    Author: Peña-Rangel MT, Riesgo-Escovar JR, Sánchez-Chávez G, Salceda R.
    Journal: Neuroreport; 2008 Aug 27; 19(13):1295-9. PubMed ID: 18695510.
    Abstract:
    The amino acid glycine is an inhibitory neurotransmitter in the spinal cord, brain stem, and vertebrate retina. The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Here, we show retinal expression of glycine transporter 1 by in-situ hybridization and of glycine transporter 2 by reverse transcriptase-PCR and in-situ hybridization. In-situ hybridization signals were observed in the ganglionar and inner nuclear layer as well as in the outer nuclear layer of the frog and rat retinas. In addition, accumulation of H-glycine was observed in isolated photoreceptor cells. The expression of these transporters in nonglycinergic cells suggests that they may also modulate electrical signals.
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