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  • Title: A clinical evaluation of the Janus Web Application, a software screening tool for drug-drug interactions.
    Author: Mannheimer B, Ulfvarson J, Eklöf S, Bergqvist M, von Bahr C.
    Journal: Eur J Clin Pharmacol; 2008 Dec; 64(12):1209-14. PubMed ID: 18695980.
    Abstract:
    PURPOSE: To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). METHODS: One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into his/her medical records provided complementing information. A clinical pharmacologist judged which potential DDIs were clinically relevant. Potentially relevant DDIs identified by the JWA were then correlated with clinically relevant DDIs. RESULTS: A total of 150 significant potential DDIs were found. Sixteen percent (24/150) were judged to be clinically relevant. CONCLUSIONS: A very small proportion of DDIs was considered clinically relevant in the specific clinical context. To optimise the software's user-friendliness, the following points need to be considered: the possibility of eliminating trivial potential DDIs, individualising drug alerts, and providing written information, accessible via a hyperlink.
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