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  • Title: Cytotoxic lanostanoid triterpenes from Ganoderma lucidum.
    Author: Guan SH, Xia JM, Yang M, Wang XM, Liu X, Guo DA.
    Journal: J Asian Nat Prod Res; 2008; 10(7-8):705-10. PubMed ID: 18696320.
    Abstract:
    Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 microm.
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