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  • Title: Synthesis and biological evaluation of novel 3'-N-tert-butylsulfonyl analogues of docetaxel.
    Author: Ke B, Qin Y, Zhao F, Qu Y.
    Journal: Bioorg Med Chem Lett; 2008 Sep 01; 18(17):4783-5. PubMed ID: 18701281.
    Abstract:
    Novel 3'-N-tert-butylsulfonyl analogues 10a-c of docetaxel were synthesized and their biological evaluation in cytotoxicity in vitro against several human tumor cell lines were presented. The biologically tested results showed that N-oxide pyridyl substituted10b-c had potent cytotoxicities against human tumor cell lines Eca-109, SKOV3, SMMC-7721, HCT-8, PC3, MCF-7, HeLa and KB.
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