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  • Title: Colonic adenoma with squamous metaplasia.
    Author: Pantanowitz L.
    Journal: Int J Surg Pathol; 2009 Aug; 17(4):340-2. PubMed ID: 18701516.
    Abstract:
    Squamous metaplasia arising within colon adenomas is a rare occurrence, with a 0.4% incidence noted predominantly in elderly males. A case of squamous metaplasia arising in a tubulovillous adenoma of the cecum, associated with adenocarcinoma, is described. Squamous metaplasia was immunoreactive for beta-catenin, but negative for cytokeratin 20, CDX2, p63, estrogen receptor, progesterone receptor, p16, and human papilloma virus. Squamous differentiation may serve as a precursor lesion for squamous neoplasia of the colorectum.
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