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  • Title: [Influence of healthy human bone marrow fibroblasts on differentiation and proliferation of human leukemic cell line HL-60].
    Author: Usui T, Nagao T, Yonekura S, Arimori S.
    Journal: Rinsho Ketsueki; 1991 May; 32(5):520-6. PubMed ID: 1870269.
    Abstract:
    The influence of bone marrow fibroblasts from healthy subjects on differentiation and clonal proliferation of HL-60 cells was studied. Clonal proliferation of HL-60 cells was examined by using agar culture method, DNA synthesis was done by counting 3H-thymidine incorporation into the cells, and differentiation of the cells was checked by non-specific esterase staining. The bone marrow fibroblasts and their conditioned-medium significantly stimulated colony formation and DNA synthesis of HL-60 cells, but they inhibited differentiation of the HL-60 cells. From these results, it was suggested that the bone marrow fibroblasts stimulated clonal proliferation of HL-60 cells and inhibited differentiation of the cells through humoral factors secreted by the fibroblasts.
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