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  • Title: Applications of next-generation sequencing technologies in functional genomics.
    Author: Morozova O, Marra MA.
    Journal: Genomics; 2008 Nov; 92(5):255-64. PubMed ID: 18703132.
    Abstract:
    A new generation of sequencing technologies, from Illumina/Solexa, ABI/SOLiD, 454/Roche, and Helicos, has provided unprecedented opportunities for high-throughput functional genomic research. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted resequencing, discovery of transcription factor binding sites, and noncoding RNA expression profiling. This review discusses applications of next-generation sequencing technologies in functional genomics research and highlights the transforming potential these technologies offer.
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