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  • Title: Molecular and kinetic properties of 15-hydroxyprostaglandin dehydrogenase (PG-15-HDH) from human placenta.
    Author: Rückrich MF, Wendel A, Schlegel W, Jackisch R, Jung A.
    Journal: Adv Prostaglandin Thromboxane Res; 1976; 1():153-7. PubMed ID: 187033.
    Abstract:
    Some molecular properties of PG-15-HDH from human term placenta were investigated. Using a computer-based weighted linear regression analysis, intersecting initial rate patterns were received for the forward reaction with the prostaglandins (PG) E1, E2, and F2alpha, respectively, and NAD as substrates. NADH exerted a linear competitive inhibition with respect to NAD. The 15-ketoprostaglandins (15-keto-PG) E1 and F2alpha showed a linear noncompetitive inhibition with respect to their corresponding PG. The kinetic patterns suggest an ordered Bi Bi mechanism of PG-15-HDH reaction. The results are discussed with respect to their possible biological significance.
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