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  • Title: Synthesis and hypnotic activities of N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives.
    Author: Byun A, Park JY, Moon KH, Park MS.
    Journal: Arch Pharm Res; 2008 Jul; 31(7):834-7. PubMed ID: 18704323.
    Abstract:
    Typical hypnotic drugs, such as barbitals and glutethimide, have a cyclic imide (-CO-NH-CO-) moiety. The N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives, which we previously showed exhibit moderate anticonvulsant activities, also have a cyclic imide (-CO-N-CO-) moiety. This structural similarity prompted us to examine the hypnotic activities of the N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives, and we describe their moderate hypnotic activities here.
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