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  • Title: Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents.
    Author: Pei X, Choi WJ, Kim YM, Zhao LX, Jeong LS.
    Journal: Arch Pharm Res; 2008 Jul; 31(7):843-9. PubMed ID: 18704325.
    Abstract:
    On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.
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