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  • Title: Sentinel node biopsy in patients with cutaneous melanoma of the head and neck: recurrence and survival study.
    Author: Gomez-Rivera F, Santillan A, McMurphey AB, Paraskevopoulos G, Roberts DB, Prieto VG, Myers JN.
    Journal: Head Neck; 2008 Oct; 30(10):1284-94. PubMed ID: 18704971.
    Abstract:
    BACKGROUND: Controversy remains regarding the benefits of sentinel lymph node (SLN) biopsy for predicting survival in cutaneous melanoma of the head and neck (CMHN). METHODS: We analyzed the factors associated with the recurrence and survival of CMHN patients treated in our institution. RESULTS: One hundred thirteen patients underwent SLN biopsy for CMHN in a 12-year period. SLN identification was successful in 96%, with a median of 3 SLNs per patient. Positive-SLNs were identified in 21%. With a median follow-up of 34 months, 28% recurred. Disease-free survival (DFS) and overall survival (OS) rates were 66% and 78% in patients with SLN-negative, and 39% and 62% in SLN-positive disease. In multivariate analysis, greater Breslow-thickness was associated with decreased DFS rate (HR 2.07, CI 1.04-4.09), and age>60 years (HR 3.53, CI 1.32-9.4) with lower 5-year OS rate. CONCLUSION: Primary tumor thickness and age were associated with decreased survival, whereas SLN status showed a trend for prognostic significance in CMHN.
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