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  • Title: Case of linear immunoglobulin A bullous dermatosis associated with acquired hemophilia.
    Author: Arakaki O, Yamamoto Y, Awazawa R, Nonaka K, Taira K, Asato Y, Hagiwara K, Oyama B, Ishii N, Hashimoto T, Uezato H.
    Journal: J Dermatol; 2008 Jul; 35(7):437-46. PubMed ID: 18705832.
    Abstract:
    Linear immunoglobulin (Ig)A bullous dermatosis is a rare autoimmune subepidermal bullous dermatosis caused by circulating IgA autoantibodies directed against the antigens at the basement membrane zone. Most linear IgA bullous dermatosis cases are idiopathic, but some are associated with the use of certain drugs, infections, lymphoproliferative disorders, internal malignancies, autoimmune disorders, collagen diseases or, very rarely, other skin diseases, including autoimmune bullous diseases. Acquired hemophilia is also rare; it is a coagulation disease caused by anti-factor VIII IgG antibodies. Acquired hemophilia has been reported to be associated with malignant tumors, pregnancy or postpartum, drug reactions, collagen diseases such as rheumatoid arthritis, autoimmune disorders, and skin diseases such as psoriasis and pemphigus. We report a case of hemophilia acquired during the course of linear IgA bullous dermatosis and review reported cases of autoimmune bullous dermatoses associated with acquired hemophilia.
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