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  • Title: Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells.
    Author: Palchaudhuri R, Hergenrother PJ.
    Journal: Bioorg Med Chem Lett; 2008 Nov 15; 18(22):5888-91. PubMed ID: 18710803.
    Abstract:
    Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure-activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell lines, including a compound with enhanced aqueous solubility.
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