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  • Title: High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides.
    Author: Kreuter A, Bischoff S, Skrygan M, Wieland U, Brockmeyer NH, Stücker M, Altmeyer P, Gambichler T.
    Journal: Arch Dermatol; 2008 Aug; 144(8):1011-6. PubMed ID: 18711073.
    Abstract:
    OBJECTIVE: To investigate the presence of human herpesvirus 8 (HHV-8) in lesional skin of German patients with large-plaque parapsoriasis (LPP) or mycosis fungoides (MF). The pathogenetic relevance of HHV-8 in cutaneous T-cell lymphoma is controversial. Recently, a highly significant association of HHV-8 in LPP was found, which suggests a role in the pathogenesis of this disease. DESIGN: Retrospective study of the presence of HHV-8 in German patients with lymphoproliferative diseases. SETTING: Dermatologic clinic at a university hospital of the Ruhr University Bochum, Bochum, Germany. PATIENTS: Fifty-three patients treated for lymphoproliferative skin diseases were included in the study, including 14 patients with LPP, 31 with different stages of MF, and 8 with lymphomatoid papulosis (LyP). Twenty-three patients with Kaposi sarcoma (KS) made up the positive control group, and 10 patients with atopic dermatitis served as negative controls. MAIN OUTCOME MEASURES: The presence of HHV-8 was analyzed from paraffin-embedded lesional tissue samples using a nested polymerase chain reaction for the open reading frame (ORF) 26 and with immunohistochemical staining for the latency-associated nuclear antigen (LANA) encoded by ORF 73. RESULTS: A high association of HHV-8 infection in both lymphoproliferative skin diseases was observed: 87% of LPP and 70% of MF tissue samples tested positive for HHV-8 DNA from ORF 26. However, HHV-8 was not detectable in LPP and MF by using the immunohistochemical marker LANA. CONCLUSIONS: A virus unambiguously associated with KS, HHV-8 was frequently detected at low amounts in LPP and MF specimens. However, based on the methods of HHV-8 detection used in this study, no conclusion can be drawn on the etiologic and pathogenetic role of HHV-8 in these diseases.
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