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  • Title: The unexpected isolation of CTP-431, a novel thiopyrone from the sponge Cacospongia mycofijiensis.
    Author: Johnson TA, Amagata T, Oliver AG, Tenney K, Valeriote FA, Crews P.
    Journal: J Org Chem; 2008 Sep 19; 73(18):7255-9. PubMed ID: 18715038.
    Abstract:
    A reinvestigation of a Fijian collection of Cacospongia mycofijiensis has yielded the known mycothiazole and a novel heterocyclic, CTP-431 (1). Its structure including absolute configuration as 8R,9R,10S,13S was established using NMR data, calculated DFT (13)C chemical shifts and results from X-ray crystallography. It is possible that the tricyclic skeleton of CTP-431 (1) is biosynthetically related to the macrolide latrunculin A, however the thiopyrone moiety of 1 has no previous precedent in natural products chemistry.
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