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  • Title: Repeated measurements of respiratory mechanics in developing rats utilizing a forced oscillation technique.
    Author: Heulitt MJ, Jones SM, Holt SJ, Thurman TL, Jo CH, Simpson PM.
    Journal: Exp Lung Res; 2008 Sep; 34(7):409-23. PubMed ID: 18716927.
    Abstract:
    The ability to successfully intubate the trachea of rats repeatedly over time, recover them, and perform repeated measures of changes in respiratory mechanics is important. The authors performed experiments utilizing 2 groups of rats at various ages in their development. Rats in the single-measurement group were studied at 1 age only. Rats in the repeated-measurement group were studied at each age point over time. Measurements of respiratory mechanics were made utilizing a forced-oscillation technique. We found no differences in respiratory mechanics between the 2 groups. Our results demonstrate that developing rats can be studied longitudinally to illustrate maturational changes in respiratory mechanics.
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