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  • Title: Brooke-Spiegler syndrome: report of a case of multiple cylindromas and trichoepitheliomas.
    Author: Doherty SD, Barrett TL, Joseph AK.
    Journal: Dermatol Online J; 2008 Jul 15; 14(7):8. PubMed ID: 18718192.
    Abstract:
    We report a case of Brooke-Spiegler syndrome, a rare autosomal dominant disorder caused by mutations of the cylindromatosis gene (CYLD) tumor suppressor gene resulting in multiple cylindromas and trichoepitheliomas. Treatment of these patients can involve surgical excision, laser therapy, or topical applications of aspirin derivatives.
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