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  • Title: Acute generalized exanthematous pustulosis due to clindamycin.
    Author: Sulewski RJ, Blyumin M, Kerdel FA.
    Journal: Dermatol Online J; 2008 Jul 15; 14(7):14. PubMed ID: 18718198.
    Abstract:
    Acute generalized exanthematous pustulosis (AGEP) is a rare skin eruption most commonly caused by medications. It is characterized by fever and the acute eruption of non-follicular pustules overlying erythrodermic skin. Histopathology shows subcorneal pustules with a background of dermal edema and spongiosis, leukocytoclastic vasculitis, perivascular eosinophils, and focal necrosis of keratinocytes. Three cases of clindamycin induced AGEP have been reported in the literature. A case of AGEP due to clindamycin is reported in a patient with numerous other drug allergies and without history of psoriasis. Presentation and treatment of AGEP are reviewed.
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