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  • Title: Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study.
    Author: Pfefferle PI, Sel S, Ege MJ, Büchele G, Blümer N, Krauss-Etschmann S, Herzum I, Albers CE, Lauener RP, Roponen M, Hirvonen MR, Vuitton DA, Riedler J, Brunekreef B, Dalphin JC, Braun-Fahrländer C, Pekkanen J, von Mutius E, Renz H, PASTURE Study GroupProtection against Allergy-Study in Rural Environments Study Group: Gertraud Weiß, Ellen Üblagger, Claudia Humer, Manuela Rußegger (Austria); Raija Juntunen, Reetta Tiihonen, Pekka Tiittanen, Anne Hyvärinen, Timo Kauppila, Aino Nevalainen, Sami Remes (Finland); Marie-Laure Dalphin, Renaud Piarroux, Gabriel Reboux, Sandrine Roussel, Bertrand Sudre (France); Susanne Schmid, Sabina Illi, Nicola Korherr, (Germany); Sondhja Bitter, Felix H. Sennhauser, Susanne Loeliger, Johanna Steinle, and Remo Frei (Switzerland)..
    Journal: J Allergy Clin Immunol; 2008 Oct; 122(4):711-716. PubMed ID: 18718651.
    Abstract:
    BACKGROUND: It is currently discussed whether allergic sensitization may start in utero under the influence of the maternal immune system and environmental determinants. OBJECTIVE: To investigate the relationship between allergen-specific cord blood (CB) IgE levels, parental sensitization, CB cytokine production, and environmental influences. METHODS: As part of an ongoing multicenter birth cohort study, allergen-specific IgE antibodies against 20 common seasonal, perennial, and food allergens were measured in blood samples from 922 neonates, 922 mothers, and 835 fathers. Supernatants from stimulated CB cells were assessed for the production of IL-5, IFN-gamma, IL-10, and TNF-alpha. RESULTS: Allergen-specific IgE antibodies were detectable in 23.9% of newborns. Contamination with maternal serum was excluded by several means of analyses, including the absence of IgA antibodies. Clear correlation between maternal and fetal IgE was found only for hen's egg, cow's milk, and soybean allergen. Fetal IgE correlated negatively with the level of IFN-gamma production, but not with IL-5 and IL-10. CONCLUSION: Allergen-specific IgE antibodies most probably of fetal origin are detectable in CB and correlate with a lowered CB IFN-gamma production.
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