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  • Title: Synthesis, structure and antitumor activity of [RhCl3(N-N)(DMSO)] polypyridyl complexes.
    Author: Sliwińska U, Pruchnik FP, Pelińska I, Ułaszewski S, Wilczok A, Zajdel A.
    Journal: J Inorg Biochem; 2008 Oct; 102(10):1947-51. PubMed ID: 18718669.
    Abstract:
    The [RhCl(3)(N-N)(DMSO)] complexes, the N-N being 2,2'-bipyridine (1), 1,10-phenanthroline (2), 4,7-diphenyl-1,10-phenanthroline (3), 4,4'-dimethyl-2,2'-bipyridine (4) and 1,10-phenanthroline-5,6-dione (5), have been synthesized and characterized with spectroscopic methods. The compounds 2-5 adopt mer- and complex 1 fac-structure. The molecular and electronic structure studies of mer- and fac-complexes with bpy and phen ligands at the DFT B3LYP level with 3-21G( * *) basis set showed that mer-isomers are more stable. The cytostatic activity of the [RhCl(3)(N-N)(DMSO)] complexes against Caco-2 and A549 tumor cells have been studied. Their antibacterial activity have also been investigated. It has been found that the very promising biological activity show complexes 2, 3 and 4.
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