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  • Title: Novel nitrofurazone derivatives endowed with antimicrobial activity.
    Author: Brondani DJ, Caetano N, Moreira DR, Soares RR, Lima VT, de Araújo JM, de Abreu FC, de Oliveira BG, Hernandes MZ, Leite AC.
    Journal: Arch Pharm (Weinheim); 2008 Oct; 341(10):655-60. PubMed ID: 18720338.
    Abstract:
    The N-alkylated derivatives from nitrofurazone were synthesised and evaluated in vitro for their efficacy as antimicrobial agents against representative strains, including methicillin-resistant Staphylococcus aureus (MRSA). The derivative 2a demonstrated greater activity than the prototype and was comparable to currently used antimicrobial drugs.
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