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  • Title: The phage K lytic enzyme LysK and lysostaphin act synergistically to kill MRSA.
    Author: Becker SC, Foster-Frey J, Donovan DM.
    Journal: FEMS Microbiol Lett; 2008 Oct; 287(2):185-91. PubMed ID: 18721148.
    Abstract:
    LysK is the endolysin from the staphylococcal bacteriophage K, and can digest the cell wall of many staphylococci. Lysostaphin is a bacteriocin secreted by Staphylococcus simulans to kill Staphylococcus aureus. Both LysK and lysostaphin have been shown to lyse methicillin-resistant S. aureus (MRSA). This study describes optimal reaction conditions for the recombinant His-tagged LysK protein (pH range pH 6-10, and 0.3-0.5 M NaCl), and C-His-LysK MIC (32.85+/-4.87 mug mL(-1)). LysK and lysostaphin demonstrate antimicrobial synergy by the checkerboard assay.
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