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  • Title: Subacute toxicity of polychlorinated naphthalenes and their effect on cytochrome P-450.
    Author: Kilanowicz A, Skrzypinska-Gawrysiak M, Sapota A, Galoch A, Daragó A.
    Journal: Ecotoxicol Environ Saf; 2009 Feb; 72(2):650-7. PubMed ID: 18722660.
    Abstract:
    The aim of the study was to investigate the subacute toxicity of a polychlorinated naphthalene (PCN) mixture and its effect on cytochrome P-450 levels in rats. The animals were administered PCNs intragastrically in repeated daily doses of 1, 10, and 100 mg/kg. The animals were dissected after 7, 14, or 21 doses. Doses of 10 and 100 mg/kg induced a significant decrease in the body weight at all time points of the experiment compared with the control group. The exposure to PCNs increased both the level of total cytochrome P-450 and the activity of CYP 1A at the same time points. In the groups of rats given PCNs in doses of 10 and 100 mg/kg, an evident dose- and time-dependent increase in malondialdehyde (MDA) level was observed throughout the experiment. The correlation between the increased MDA and decreased glutathione (GSH) levels in the liver was also observed.
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