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  • Title: The protozoan toxin climacostol inhibits growth and induces apoptosis of human tumor cell lines.
    Author: Buonanno F, Quassinti L, Bramucci M, Amantini C, Lucciarini R, Santoni G, Iio H, Ortenzi C.
    Journal: Chem Biol Interact; 2008 Nov 25; 176(2-3):151-64. PubMed ID: 18723007.
    Abstract:
    Climacostol (5-(Z)-non-2-enyl-benzene-1,3-diol) is a natural toxin isolated from the freshwater ciliated protozoan Climacostomum virens and belongs to the group of resorcinolic lipids, compounds that show antimicrobial, antiparasitic and antitumor activities. We investigated the cytotoxic activity of the chemically synthesized toxin on: (1) human tumor squamous carcinoma A431 cells, (2) human promyelocytic leukaemia HL60 cells, and (3) human non-tumor endothelial EA.hy926 cells. The results showed that climacostol effectively inhibited the growth of tumor cell lines in a dose-dependent manner by inducing programmed cell death, with non-tumor cells proving significantly more resistant to the toxin.
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