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  • Title: [Tumor markers--personal experience. A case report of primary lung cancer with interesting production of tumor markers].
    Author: Ariyoshi Y.
    Journal: Gan To Kagaku Ryoho; 1991 Aug; 18(10):1721-5. PubMed ID: 1872630.
    Abstract:
    Three interesting cases of primary lung cancer from the standpoint of tumor marker production were reported. The first was a case of double cancers, one of which was sigmoid cancer without CEA production and the other a large cell lung cancer with CEA production. The evidence of elevated serum CEA level initially led to a wrong diagnosis as sigmoid cancer with lung metastasis. The second was a case which showed a relapse of monotonous cancer without CEA production after surgical removal of lung cancer tissue containing heterogeneous cancer cells. Elevated serum CEA levels were never observed after the operation, although the preoperative serum test was positive for CEA. The last was a case of squamous cell lung cancer which showed trophoblastic differentiation accompanied with massive hCG production. Very rapid tumor cell growth was seen after the early relapse following the operation. Positivity for hCG staining varied among primary and metastatic tumor tissues.
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