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  • Title: [A case of ABO*Ael02/O04 genotype with typical phenotype O].
    Author: Joo SY, Shim YS, Kim MJ, Kwon HL, Lee K, Chang HE, Song SH, Park KU, Song J, Han KS.
    Journal: Korean J Lab Med; 2008 Aug; 28(4):319-24. PubMed ID: 18728383.
    Abstract:
    Ael is a rare blood type which has the least amount of A antigen among A subgroups. It can be detected by special tests performed to resolve the discrepancy between red cell and serum typing in routine serological typing. The presence of A antigen on Ael red cell is demonstrable only by adsorption and elution tests. An Ael individual does not secret A substance in the saliva and may have anti-A antibody in the serum which is usually less reactive with the reagent red cells than anti-B antibody. In Korea, Ael02 has been reported more frequently than other Ael alleles. We report a case of Ael02/O04 who presented as typical phenotype O with strong anti-A and anti-B antibodies and no A antigen detected even by adsorption and elution tests. The case has been proved to be Ael02/O04 by direct sequencing analysis. In individuals with history of discrepancies in the results of ABO phenotyping, ABO genotyping is needed for an accurate evaluation of their blood type.
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