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  • Title: Antibacterial potential of Antarctic lichens against human pathogenic Gram-positive bacteria.
    Author: Paudel B, Bhattarai HD, Lee JS, Hong SG, Shin HW, Yim JH.
    Journal: Phytother Res; 2008 Sep; 22(9):1269-71. PubMed ID: 18729247.
    Abstract:
    Extracts from five Antarctic lichens (L3, Stereocaulon alpinum; L5, Ramalina terebrata; L6, Caloplaca sp.; L8, Lecanora sp.; and L17, Caloplaca regalis) were tested for antimicrobial activities against several clinically important microbes by disk diffusion. The minimum inhibitory concentration (MIC) of each extract was determined by a broth dilution method. Extracts from L3, L5, L6 and L8 were active against two Gram(+) strains. B. subtilis was more sensitive to lichen extracts (except L5) than S. aureus. The MIC of lichen extracts against B. subtilis and S. aureus was observed from 36.7 +/- 0.3 to 953.8 +/- 85.8 microg/mL and 68.5 +/- 0.6 to >1000 microg/mL, respectively. Comparisons of MIC values of Antarctic lichen crude extracts to previously published MIC values of some reported lichen metabolites against Gram(+) bacteria indicated that Antarctic lichens might be an enriched source of effective antibacterial agents against clinically relevant Gram(+) species.
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