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  • Title: Interleukin-2 and syngeneic bone marrow transplantation in a murine fibrosarcoma model.
    Author: Ho SP, Stebler B, Ershler WB.
    Journal: Lymphokine Cytokine Res; 1991 Apr; 10(1-2):101-4. PubMed ID: 1873353.
    Abstract:
    Mice received interleukin-2 (IL-2) either before and after, or just after intravenous inoculation of syngeneic fibrosarcoma cells. Fewer pulmonary tumor colonies were observed in those animals treated with IL-2, and the best results were observed when IL-2 was administered prior to tumor inoculation. When mice were lethally irradiated and reconstituted with tumor-contaminated bone marrow, IL-2 treatment was also associated with fewer tumor lung colonies. IL-2 may prove to be a useful adjuvant therapy, particularly in the setting of autologous bone marrow transplantation when the infused marrow is contaminated with tumor cells.
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