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  • Title: Benzodiazepines and discrimination behaviour: dissociation of response and sensory factors.
    Author: Tye NC, Sahgal A, Iversen SD.
    Journal: Psychopharmacology (Berl); 1977 Apr 29; 52(2):191-4. PubMed ID: 18751.
    Abstract:
    Ten London pigeons were trained on a schedule which allowed concurrent measurement of motor and exteroceptive sensory changes. The task involved a conditional colour discrimination contingent upon the completion of a fixed interval schedule of responding. As a preliminary pharmacological study the effects of the benzodiazepines, chlordiazepoxide and flurazepam were investigated. Both drugs enhanced perseverative responding (after completion of the FI), and to a variable degree responding during the FI, although there was no evidence for an increase in responding during the inter-trial-intervals. On the other hand, no marked changes in discrimination performance were observed. It is concluded that the most significant effects of these benzodiazepines are on motor mechanisms.
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