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  • Title: Aldosterone antagonists. 4. Synthesis and activities of steroidal 6,6-ethylene-15,16-methylene 17-spirolactones.
    Author: Nickisch K, Beier S, Bittler D, Elger W, Laurent H, Losert W, Nishino Y, Schillinger E, Wiechert R.
    Journal: J Med Chem; 1991 Aug; 34(8):2464-8. PubMed ID: 1875342.
    Abstract:
    Several steroidal 6,6-ethylene-15,16-methylene 17-spirolactones were synthesized to find new progestogens that exhibit both progestational and antimineralocorticoidal activities. The influence of substituents in the 10- and 13-position of the steroidal framework on both properties was investigated. It was found that only compound 12, carrying methyl groups at the 10- and 13-positions, possesses high progestational and antimineralocorticoidal activity.
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