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  • Title: [Various aspects of the anti-aggregatory action of diltiazem and cordaphene in patients with ischemic heart disease].
    Author: Leonova MV, Rumiantsev DO, Belousov IuB.
    Journal: Kardiologiia; 1991 Mar; 31(3):13-6. PubMed ID: 1875587.
    Abstract:
    Some aspects of the antiaggregatory action of calcium antagonists were studied in 50 patients with stable angina pectoris. Dilzem (diltiazem) and cordaphene (nifedipine) were tested for their effects on the erythrocytic component of hemostasis, taking into account their capability of suppressing hemolysis, which made ADP, an important thrombocytic activator, enter the blood flow. The two agents significantly reduce the concentration of plasma ADP, free hemoglobin, diminish mechanical erythrocytic resistance, and block platelet aggregation to a varying degree. A relationship was established between the levels of blood nifedipine and the magnitude of rheological effects. With this, the patients with coronary heart disease showed a good antianginal effect.
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