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  • Title: Aberrant DNA methylation of the transcription factor C/EBPalpha in acute myelogenous leukemia.
    Author: Jost E, do O N, Wilop S, Herman JG, Osieka R, Galm O.
    Journal: Leuk Res; 2009 Mar; 33(3):443-9. PubMed ID: 18757096.
    Abstract:
    We investigated the methylation status of the CCAAT/enhancer binding protein alpha (C/EBPalpha) promoter region near the transcription start site in acute myelogenous leukemia (AML). In hematopoietic tumor cell lines, CpG island hypermethylation of the proximal C/EBPalpha promoter region was associated with transcriptional silencing, and treatment with the demethylating agent 5-aza-2'-deoxycytidine resulted in C/EBPalpha reexpression and promoter demethylation. Aberrant methylation of the C/EBPalpha promoter region occurred in 10/80 diagnostic AML samples, and there was an inverse correlation between aberrant methylation of C/EBPalpha and the negative cell cycle regulator p15. Our results provide further evidence for epigenetic dysregulation of C/EBPalpha in AML.
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