These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lower environmental temperature: effect of long-term exposure on diazepam-induced changes in brain GABA.
    Author: Biswas S, Mukhopadhyay S, Poddar MK.
    Journal: Methods Find Exp Clin Pharmacol; 1991 May; 13(4):255-61. PubMed ID: 1875774.
    Abstract:
    Long-term diazepam (DZ) treatment (5 mg/kg, i.p. for 15-30 consecutive days) reduced GABAergic activity in hypothalamus and cerebellum with the alteration of GABA synthesis and its release process. This long-term DZ-induced inhibition in GABAergic activity in hypothalamus and cerebellum was not altered when DZ-treated rats were exposed (2 h/day) to lower environmental temperature (LET; 12 degrees C) for 7-30 consecutive days. Although repeated exposure to LET did not affect the GABA system in cerebellum and hypothalamus, striatal GABAergic activity was significantly enhanced under similar conditions. This LET-induced (repeated exposure) stimulation in striatal GABAergic activity was prevented when rats were treated with DZ along with repeated LET exposure (2 h/day) under long-term conditions.
    [Abstract] [Full Text] [Related] [New Search]