These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Three aryl-substituted tetrahydro-1,4-epoxy-1-benzazepines: hydrogen-bonded structures in two or three dimensions.
    Author: Gómez SL, Raysth W, Palma A, Cobo J, Low JN, Glidewell C.
    Journal: Acta Crystallogr C; 2008 Sep; 64(Pt 9):o519-23. PubMed ID: 18758025.
    Abstract:
    In (2SR,4RS)-7-chloro-2-exo-(4-chlorophenyl)-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, C(16)H(13)Cl(2)NO, (I), the molecules are linked by a combination of C-H...O and C-H...N hydrogen bonds into a chain of edge-fused R(3)(3)(12) rings. The isomeric compound (2S,4R)-7-chloro-2-exo-(2-chlorophenyl)-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, (II), crystallizes as a single 2S,4R enantiomer and the molecules are linked into a three-dimensional framework structure by two C-H...O hydrogen bonds and one C-H...pi(arene) hydrogen bond. The molecules of (2S,4R)-7-chloro-2-exo-(1-naphthyl)-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, C(20)H(16)ClNO, (III), are also linked into a three-dimensional framework structure, here by one C-H...O hydrogen bond and two C-H...pi(arene) hydrogen bonds. The significance of this study lies in its observation of the variations in molecular configuration and conformation, and in the variation in the patterns of supramolecular aggregation, consequent upon modest changes in the peripheral substituents.
    [Abstract] [Full Text] [Related] [New Search]