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  • Title: An intraosseous malignant peripheral nerve sheath tumor of the cervical spine: a case report and review of the literature.
    Author: Moon SJ, Lee JK, Seo BR, Kim JH, Kim SH, Lee KH, Lee MC.
    Journal: Spine (Phila Pa 1976); 2008 Sep 01; 33(19):E712-6. PubMed ID: 18758353.
    Abstract:
    STUDY DESIGN: Case description. OBJECTIVES: To report a rare case of intraosseous malignant peripheral nerve sheath tumors (MPNST), and review the pertinent medical literature. SUMMARY OF BACKGROUND DATA: The spinal MPNST that develops from spinal nerve roots and secondary bony erosion is well-known entity. However, primary intraosseous MPNSTs of the spine are extremely rare. METHODS: A 41-year-old male presented with a 1-month history of radiating pain to his right shoulder and arm. Magnetic resonance images showed a large extradural mass extending from C6 to T1 with destruction of the posterior elements of C6, C7, and T1. Complete excision of the tumor and posterior stabilization were performed through a posterior approach. The tumor was noted to originate from the posterior element of C7. RESULTS: The histopathology was diagnostic for a MPNST. Adjuvant chemotherapy was administered after surgery. The patient remained symptom-free for 30 months after surgery without local recurrence or metastasis. CONCLUSION: We report an intraosseous MPNST of the cervical spine. Complete surgical excision and adjuvant chemotherapy resulted in a good functional outcome. MPNST should be added to the differential diagnosis of primary bone tumors causing spinal cord compression.
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