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  • Title: Membrane redox state and apoptosis: death by peroxide.
    Author: Loscalzo J.
    Journal: Cell Metab; 2008 Sep; 8(3):182-3. PubMed ID: 18762018.
    Abstract:
    Membrane redox state is governed by the complex interplay between oxidation of unsaturated fatty acids and lipophilic antioxidants. In this issue of Cell Metabolism, Seiler et al. (2008) show that a lipid oxidase, 12/15-lipoxygenase, and a membrane antioxidant enzyme, glutathione peroxidase-4, interact to regulate a novel redox-dependent cell death pathway.
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