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  • Title: In vitro interactions of itraconazole and micafungin against clinically important filamentous fungi.
    Author: Ruíz-Cendoya M, Rodriguez MM, Mariné M, Pastor FJ, Guarro J.
    Journal: Int J Antimicrob Agents; 2008 Nov; 32(5):418-20. PubMed ID: 18762407.
    Abstract:
    The in vitro interactions between itraconazole and micafungin against 133 strains of filamentous fungi of clinical interest were evaluated using a checkerboard method. Overall, synergistic interactions were observed against 30% of the strains tested. In the cases of Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Fonsecaea spp. and Sporothrix schenckii, synergistic interactions were observed against > or = 50% of the strains tested. For the rest of the fungi the interaction was indifferent; antagonism was not observed in any case.
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