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  • Title: [Therapeutic drug monitoring: clinical practice].
    Author: Widmer N, Werner D, Grouzmann E, Eap CB, Marchetti O, Fayet A, Csajka C, Decosterd LA, Buclin T.
    Journal: Rev Med Suisse; 2008 Jul 16; 4(165):1649-50, 1652-60. PubMed ID: 18767291.
    Abstract:
    When requesting a blood level measurement in the context of "Therapeutic drug monitoring" (TDM), numerous aspects have to be considered in the pre-analytical and analytical area, as in the integration of associated clinical data. This review presents therapeutic classes for which a clinical benefit of TDM is established or suggested, at least in some settings. For each class of drugs, the main pharmacokinetic, pre-analytical, analytical and clinical aspects are evaluated in the scope of such a monitoring. Each step of the TDM process is important and none should be neglected. Additional clinical trials are however warranted to better establish the exact conditions of use for such a monitoring.
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