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  • Title: [Impact of serotonin 1A receptors in the kappa-opioid immunosuppression].
    Author: Cheĭdo MA, Idova GV.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2008 Jul; 94(7):807-13. PubMed ID: 18767393.
    Abstract:
    The data obtained indicate that rimorphin (0.1 mg/kg), a specific kappa-agonist, evoked a significant inhibition of the immune response in CBA mice. Pretreatment of the animals with 8-OH-DPAT (0.1 mg/kg), a selective serotonin (5-HT) agonist, activating presynaptic 5-HT(1A) receptors, or WAY-100635 (1.0 mg/kg), a selective 5-HT(1A) receptors blocker of postsynaptic 5-HTIA receptors, prevents kappa-opioid effect. The present data indicate that kappa-opioid-induced immunosuppression is due to the involvement of the 5-HT-ergic mechanisms that are modulated via pre- and postsynaptic 5-HT(1A) receptors.
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